MULTISTAGE DELIVERY OF ACTIVE AGENTS

摘要

Multistage delivery vehicles are disclosed which include a first stage particle and a second stage particle. The first stage particle is a micro or nanoparticle that contains the second stage particle. The second stage particle includes an active agent, such as a therapeutic agent or an imaging agent. The multistage delivery vehicle allows sequential overcoming or bypassing of biological barriers. The multistage delivery vehicle is administered as a part of a composition that includes a plurality of the vehicles. Methods of making the multistage delivery vehicles are also provided.

主权项

1. A multistage delivery composition comprising:
a first stage particle containing a second stage particle, wherein the first stage particle comprises: (i) a body; (ii) at least one surface with a surface charge; and (iii) a plurality of nanoscale reservoirs in the body of the first stage particle, each reservoir connected to at least one surface of the body, such that at least one of the plurality of the nanoscale reservoirs contains the second stage particle, and wherein:
the first stage particle is biodegradable and has a selected non-spherical shape;the first stage particle is a porous micro or nanoparticle with a size from about 100 nm to about 5 microns;the second stage particle comprises an active agent;the first stage particle is configured to overcome a first biological barrier; andthe second stage particle is configured to overcome a second biological barrier, wherein the first stage particle and the second stage particle are configured to sequentially overcome the first biological barrier and second barrier respectively.