| 发明名称 | Antibody vaccine conjugates and uses therefor | ||
| 摘要 | The present invention provides novel antibody vaccine conjugates and methods of using the same to induce a cytotoxic T cell (CTL) response. In a particular, embodiment, the vaccine conjugate includes a human chorionic gonadotropin beta subunit (βhCG) antigen linked to an anti-mannose receptor (MR) antibody. | ||
| 申请公布号 | US9259459(B2) | 申请公布日期 | 2016.02.16 |
| 申请号 | US200410903191 | 申请日期 | 2004.07.30 |
| 申请人 | Celldex Therapeutics Inc. | 发明人 | Keler Tibor;Endres Michael;He Lizhen;Ramakrishna Venky |
| 分类号 | C07K14/52;A61K39/00;C07K14/59;C07K16/28 | 主分类号 | C07K14/52 |
| 代理机构 | Nelson Mullins Riley & Scarborough LLP | 代理人 | Nelson Mullins Riley & Scarborough LLP ;Remillard, Esq. Jane E.;Sloper, Esq. Jill Gorny |
| 主权项 | 1. A composition formulated without an adjuvant or immunostimulatory agent comprising a molecular conjugate of a monoclonal antibody that binds to human macrophage mannose receptor (MMR) linked to βhCG, wherein the molecular conjugate is internalized and processed by APCs, such that a T cell-mediated immune response is generated against βhCG. | ||
| 地址 | Needham MA US | ||