Patient specific planning and simulation of ablative procedures

摘要

Patient specific temperature distribution in organs, due to an ablative device, is simulated. The effects of ablation are modeled. The modeling is patient specific. The vessel structure for a given patient, segmented from medical images, is accounted for as a heat sink in the model of biological heat transfer. A temperature map is generated to show the effects of ablation in a pre-operative analysis. Temperature maps resulting from different ablation currents and ablation device positions may be used to determine a more optimal location of the ablative device for a given patient. Other models may be included, such as accounting for the tissue damage during the ablation.

主权项

1. A method for patient specific computation of a temperature map under ablation therapy, the method comprising:
acquiring, with an imaging system, data representing vessels and tissue in a tissue region of a patient; modeling a heat sink in the tissue with a computational fluid dynamics model, modeling of the heat sink being a function of locations of the vessels in the tissue region of the patient from geometrical data and blood flow boundary conditions acquired from the data representing the vessels and the tissue region, or nominal physiological values; modeling biological heat transfer in the tissue region as a function of tissue thermal conductivity, modeling biological heat transfer in the tissue region as a function of small scale perfusion based on vasculature flow computed from computational fluid dynamics, calculating a temperature boundary condition from a model of an ablation device, and computing a temperature map comprising the boundary conditions, with the modeling of the heat sink, the modeling of the biological heat transfer as a function of the tissue thermal conductivity, and the modeling of the biological heat transfer as a function of the small scale perfusion.