| 发明名称 |
POLYPEPTIDES TARGETING VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 AND ALPHA V BETA 3 INTEGRIN |
| 摘要 |
Polypeptides comprising variant vascular endothelial growth factor sequences are provided. The polypeptides are useful in cancer imaging, cancer diagnosis, monitoring and treatment as well as treatment of diseases characterized by excessive neovascularization. |
| 申请公布号 |
US2016039895(A1) |
申请公布日期 |
2016.02.11 |
| 申请号 |
US201514828319 |
申请日期 |
2015.08.17 |
| 申请人 |
The Board of Trustees of the Leland Stanford Junior University |
发明人 |
Cochran Jennifer R.;Silverman Adam;Jones Douglas;Papo Niv |
| 分类号 |
C07K14/475 |
主分类号 |
C07K14/475 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A vascular endothelial growth factor (VEGF) variant polypeptide, comprising:
(a) a first VEGF polypeptide having an amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 2, and (b) a second VEGF polypeptide having an amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 2, and further comprising an integrin-recognition RGD motif containing loop that replaces loop 1, loop 2, or loop 3, of the second VEGF polypeptide; wherein the VEGF variant polypeptide is a single-chain. |
| 地址 |
Stanford CA US |
