发明名称 |
MODIFIED INTEGRIN POLYPEPTIDES, MODIFIED INTEGRIN POLYPEPTIDE DIMERS, AND USES THEREOF |
摘要 |
Described herein are modified integrin α and/or β headpiece polypeptides, and crystallizable integrin polypeptide dimers comprising a modified integrin α and/or β headpiece polypeptide and a disulfide bond linking the two integrin headpiece polypeptide subunits. Methods for using the modified integrin α and/or β headpiece polypeptides and the integrin polypeptide dimers are also provided herein. For example, methods for characterizing integrin-ligand interaction and identifying integrin ligands are also provided herein. In some embodiments, the identified integrin ligands can be used as inhibitors of integrins. |
申请公布号 |
WO2016022851(A1) |
申请公布日期 |
2016.02.11 |
申请号 |
WO2015US44093 |
申请日期 |
2015.08.06 |
申请人 |
CHILDREN'S MEDICAL CENTER CORPORATION |
发明人 |
SPRINGER, TIMOTHY ALAN;DONG, XIANCHI;LU, CHAFEN |
分类号 |
C07K14/705 |
主分类号 |
C07K14/705 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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