| 发明名称 |
COMBINATION THERAPY WITH GLUTAMINASE INHIBITORS |
| 摘要 |
The invention relates to methods of treating cancer, myeloproliferative diseases, or immunological or neurological diseases with a combination of a glutaminase inhibitor and an anticancer agent such as an enzyme inhibitor (such as a kinase inhibitor), a mitotic inhibitor, a DNA-modifying agent, or a cytidine analog. The invention further relates to methods of treating cancer, myeloproliferative diseases, or immunological or neurological diseases that are resistant to one or more anticancer agents. |
| 申请公布号 |
US2016022674(A1) |
申请公布日期 |
2016.01.28 |
| 申请号 |
US201514738279 |
申请日期 |
2015.06.12 |
| 申请人 |
Calithera Biosciences, Inc. |
发明人 |
Steggerda Susanne M.;MacKinnon Andrew L.;Rodriguez Mirna L.;Zhang Dong;Parlati Francesco |
| 分类号 |
A61K31/501;A61N5/10;A61K31/436;A61K31/517;A61K45/06;A61K31/502 |
主分类号 |
A61K31/501 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating or preventing cancer, a myeloproliferative disease, an immunological disease, or a neurological disease, comprising conjointly administering a glutaminase inhibitor and an anticancer agent selected from an enzyme inhibitor, a mitotic inhibitor, a DNA-modifying agent, and a cytidine analog. |
| 地址 |
South San Francisco CA US |
