HUMAN ANTIBODIES TO NAV1.7

摘要

The present invention provides antibodies that bind to the human voltage gated sodium channel designated Nav 1.7 and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human Nav 1.7 (hNav 1.7). The antibodies of the invention are useful for the treatment of diseases and disorders associated with one or more Nav 1.7 biological activities, including the treatment of acute or chronic pain conditions, or inflammatory conditions.

主权项

1. An isolated human antibody or antigen-binding fragment of a human antibody that specifically binds to at least one extracellular (EC) loop, or a fragment thereof, or to the paddle region, or a fragment thereof, of human Nav 1.7.