| 发明名称 | Influenza nucleoprotein vaccines | ||
| 摘要 | The present invention is related to a fusion protein comprising a variant of a nucleoprotein antigen from Influenza strain A, B or C, and a variant of a C4bp oligomerization domain for increasing the cellular immunogenicity of the nucleoprotein antigen from Influenza. The invention is also related to nucleic acids, vectors, fusion proteins and immunogenic compositions, for their use as a vaccine or immunotherapy for the prevention and treatment of influenza disease. | ||
| 申请公布号 | US9243047(B2) | 申请公布日期 | 2016.01.26 |
| 申请号 | US201414570155 | 申请日期 | 2014.12.15 |
| 申请人 | Imaxio | 发明人 | Del Campo Ascarateil Judith;Hill Fergal |
| 分类号 | C07K14/47;C07K14/005;A61K47/48;C07K14/435;C07K14/445 | 主分类号 | C07K14/47 |
| 代理机构 | Banner & Witcoff, Ltd. | 代理人 | Banner & Witcoff, Ltd. |
| 主权项 | 1. A fusion protein comprising at least one variant of the nucleoprotein antigen (NP) and a variant of the carrier protein of sequence SEQ ID NO: 1 comprising a C-terminal substitution of at least one positively-charged peptide having the sequence ZXBBBBZ (SEQ ID NO: 3) wherein (i) Z is any amino acid or is absent, (ii) X is any amino acid and (iii) B is an arginine (R) or a lysine (K). | ||
| 地址 | FR | ||