发明名称 |
Dispiro-1,2,4-trioxolaner som antimalariamidler |
摘要 |
A means and method for treating malaria, schistosomiasis, and cancer using a dispiro 1,2,4-trioxolane is described. The 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side of the trioxolane group, whereby the spirocyclohexyl ring is substituted at the 4-position. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites. |
申请公布号 |
DK1514871(T3) |
申请公布日期 |
2016.01.25 |
申请号 |
DK20040254821T |
申请日期 |
2004.08.11 |
申请人 |
MMV MEDICINES FOR MALARIA VENTURE |
发明人 |
VENNERSTROM, JONATHAN L., UNIV.OF NEBRASKA MED. C.;TANG, YUANQUING, UNIVERSITY OF NEBRASKA MEDIC.CEN.;DONG, YUXIANG UNIVERSITY OF NEBRASKA MEDIC.CENTER;MATILE, HUGHES, PHARMA RESEARCH DEPARTMENT,;CHARMAN, WILLIAM N., VICTORIAN COLLEGE OF PHARMACY;CHOLLET, JAQUES, SWISS TROPICAL INSTITUTE;PADMANILAYAM, MANIYAN;YATENDRA, KUMAR;GYAN, CHAND YADAV |
分类号 |
C07D405/12;A61K31/335;A61K31/357;A61K31/4025;A61K31/41;A61K31/4178;A61K31/4196;A61K31/443;A61K31/4525;A61K31/455;A61K31/4747;A61K31/497;A61K31/506;A61K31/5377;A61K31/541;A61P33/06;A61P33/12;C07D323/02;C07D405/06;C07D417/06 |
主分类号 |
C07D405/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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