发明名称 |
RAPID AND INEXPENSIVE ASSAY FOR EVALUATION OF ANTIBODY EFFICACY WITH CUSTOM-DESIGNED FLOURESCENT NANOPARTICLES |
摘要 |
<p>A method for determining the efficacy of a vaccine comprising: providing serum from an animal inoculated with a vaccine; providing a plurality of antigen-linked nanoparticles; contacting the serum with the plurality of antigen linked nanoparticles; contacting the serum and the plurality of antigen linked nanoparticles with a plurality of Fc receptor-expressing cells; measuring amount antigen-linked nanoparticle uptake by of the Fc receptor-expressing cells; determining efficacy of the vaccine by comparing the level of antigen-linked nanoparticle uptake to a baseline level of uptake wherein a greater nanoparticle uptake compared to the baseline level of uptake is indicative of greater vaccine efficacy.</p> |
申请公布号 |
EP2972341(A1) |
申请公布日期 |
2016.01.20 |
申请号 |
EP20140763510 |
申请日期 |
2014.03.15 |
申请人 |
SOUTH DAKOTA BOARD OF REGENTS |
发明人 |
HUBER, VICTOR;SEREDA, GRIGORIY;DALE, JAMES |
分类号 |
G01N33/53;G01N33/551;G01N33/567 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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