发明名称 |
METAL-CATALYZED ASYMMETRIC 1,4-CONJUGATE ADDITION OF VINYLBORON COMPOUNDS TO 2-SUBSTITUTED-4-OXY- CYCLOPENT-2-EN-1-ONES YIELDING PROSTAGLANDINS AND PROSTAGLANDIN ANALOGS |
摘要 |
This invention provides a novel method for the preparation of 2,3- disubstituted-4-oxy-cyclopentan-l-one compounds that are useful for the synthesis of prostaglandins and prostaglandin analogs of industrial relevance. The method comprises the metal -catalyzed asymmetric 1,4-conjugate addition of vinylboron compounds to 2- substituted-4-oxy-cyclopent-2-en-l-ones. This method relies on the use of less toxic, easily- handled reagents, and can be performed under milder conditions than offered by some conventional methods, affording 2,3-disubstituted-4-oxy-cyclopentan-l-one compounds enantio- and diastereoselectively, which are precursors to the said prostaglandin and prostaglandin analogs, in high yield. |
申请公布号 |
CA2952927(A1) |
申请公布日期 |
2016.01.14 |
申请号 |
CA20152952927 |
申请日期 |
2015.07.09 |
申请人 |
SCINOPHARM TAIWAN, LTD. |
发明人 |
HENSCHKE, JULIAN PAUL;WU, PING-YU;WU, HSYUEH-LIANG;WEN, WEN-HSIEN |
分类号 |
C07C45/61;C07C45/65;C07C49/647;C07C69/003 |
主分类号 |
C07C45/61 |
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