IMMUNE ASSAY

摘要

The invention relates to a method of identifying a modulator of the immune response system, comprising assaying for the effect of a compound on the internalisation and recycling of CTLA-4 in a cell, wherein an increase in cycling of CTLA-4 compared to a control without the compound indicates that the compound suppresses the immune response and a decrease in the cycling of CTLA-4 compared to a control without the compound, indicates that the compound increases the immune response. The cycling of CTLA-4 may be determined by monitoring CTLA-4 or monitoring uptake of a CTLA-4 label into a cell.