Translocation and nucleotide reading mechanisms for sequencing nanodevices

摘要

By driving molecules electrophoretically through a nanopore, single molecule detection can be achieved. To enhance translocational control, functionalized and non-functionalized electrodes are strategically placed around or above a nanopore. Changes in transmission spectra and input voltage detected by electrodes allow accurate identification of single molecules as they pass through a nanopore.

主权项

1. A device to translocate molecules, comprising:
a first molecule channel along which translocation of the molecules is adapted to occur along a first direction; and a first set of teeth jointly moveable back and forth in a same teeth direction substantially perpendicular to the first direction, wherein joint movement back and forth of the first set of teeth in the same teeth direction causes the translocation of the molecules in the first molecule channel along the first direction.