| 摘要 |
The present invention relates to a lung model device for testing inhalation toxicity. By placing multiple mesh tissue panels, attached with lung cells, inside a case, the model device can become similar to the lungs of a person. Also, by supplying air and nanoparticles into the case through an additional respiration operation unit, the status change of the lung cells, due to the toxicity of nanoparticles, can be indirectly and conveniently investigated without using live experimental animals. Therefore, the present invention can be an alternative to traditional methods for testing inhalation toxicity of nanoparticles. By orderly placing the mesh tissue panels from big to small sizes along the in-flowing direction of nanoparticles, the structure can much resemble the real lungs of a person, thereby increasing the accuracy of an inhalation toxicity test without using experimental animals. |
