发明名称 |
THERMOSENSITIVE HYDROGEL COLLAGENASE FORMULATIONS |
摘要 |
It is an object of the present disclosure to provide a formulation for injectable and topical collagenase, which will have extended residence time for the drug at the therapeutic targeted area for the indication being treated. It is a further object of the disclosure to provide a slow release formulation for collagenase, which is compatible with the active ingredient and does not adversely affect its activity. Still a further object of the disclosure is to provide an injectable formulation for collagenase which can be effectively administered to a patient with a small size needle without exhibiting pre-gelation, which would interfere with the ability to deliver the required dose for treatment. Still a further object of the disclosure is to provide a water-based topical formulation for collagenase which will be more compatible with other topically used medications to achieve better results. |
申请公布号 |
US2016000890(A1) |
申请公布日期 |
2016.01.07 |
申请号 |
US201514853245 |
申请日期 |
2015.09.14 |
申请人 |
BioSpecifics Technologies Corp. |
发明人 |
Yu Bo;Wegman Thomas L. |
分类号 |
A61K38/48;B65D85/00;A61K47/18;A61K47/34;A61K47/32 |
主分类号 |
A61K38/48 |
代理机构 |
|
代理人 |
|
主权项 |
1. A composition for treating a collagen-mediated disease, comprising collagenase and a carrier that provides sustained release of an amount of said collagenase sufficient to treat said collagen-mediated disease. |
地址 |
Lynbrook NY US |