Fused Imidazole Derivatives Useful as IDO Inhibitors

摘要

Presently provided are IDO inhibitors and pharmaceutical compositions thereof, useful for modulating an activity of indoleamine 2,3-dioxygenase; treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression; treating a medical conditions that benefit from the inhibition of enzymatic activity of indoleamine-2,3-dioxygenase; enhancing the effectiveness of an anti-cancer treatment comprising administering an anti-cancer agent; treating tumor-specific immunosuppression associated with cancer; and treating immunosuppression associated with an infectious disease.

主权项

1. A compound of the formula,or a pharmaceutically acceptable salt thereof, wherein
bond a is a single bond or a double bond; n is 0 or 1; each R1 is independently halogen, —OR, —N(R)2, or —SR; m is 0, 1, or 2; p is 0 or 1; when a is a single bond, then Z is —N(R35)—, wherein
R35 is hydrogen, C1-6alkyl, —C(O)R, —S(O)2R, —C(O)OR, —C(O)N(R)2, —S(O)2OR, or —S(O)2N(R)2; when a is a double bond, then Z is —N═; each R31 is independently halogen, cyano, nitro, C1-6alkyl, —C1-6alkyl-R33, C1-6haloalkyl, —OR, —N(R)2, —SR, —C(O)OR, —C(O)N(R)2, —C(O)R, —S(O)R, —S(O)OR, —S(O) N(R)2, —S(O)2R, —S(O)2OR, —S(O)2N(R)2, —OC(O)R, —OC(O)OR, —OC(O)N(R)2, —N(R)C(O)R, —N(R)C(O)OR, —N(R)C(O)N(R)2, wherein R33 is —OR, —N(R)2, or —SR; RC is hydrogen or C1-6alkyl; and each R is independently hydrogen, C1-6alkyl, C1-6haloalkyl, phenyl, 5- or 6-membered heteroaryl, C3-8cycloalkyl, C3-8cycloalkenyl, 3-8 membered heterocyclyl, benzyl, (5- or 6-membered heteroaryl)C1-6alkyl-, C3-8 cycloalkylC1-6alkyl-, C3-8cycloalkenylC1-6alkyl-, or (3-8 membered heterocyclyl)C1-6alkyl-.