| 摘要 |
The invention relates to the administration of inhibitors of phosphodiesterase 1 (PDE1) for the treatment of diseases or disorders characterized by disruption of or damage to various cGMP/PKG mediated pathways. In one embodiment the invention relates to inhibitors of phosphodiesterase 1 (PDE1) for treatment of cardiovascular disease and related disorders, e.g., congestive heart disease, atherosclerosis, myocardial infarction, and stroke. |
| 主权项 |
1. A method of treatment or prophylaxis of a condition which may be ameliorated by modulating cGMP/PKG-dependent signaling pathways comprising administration of a PDE1 inhibitor to a patient in need thereof, wherein the disease or disorder is selected from the group consisting of: cardiovascular disease, angina, stroke, renal failure, essential hypertension, pulmonary hypertension, secondary hypertension, isolated systolic hypertension, hypertension associated with diabetes, hypertension associated with atherosclerosis, renovascular hypertension, congestive heart failure, myocardial infarction, an inflammatory disease or disorder, Duchenne muscular dystrophy, Becker muscular dystrophy, limb-girdle muscular dystrophy, myotonic dystrophy, Emery-Dreifuss muscular dystrophy and a connective tissue disease or disorder (e.g., Marfan Syndrome). |
