NEAR-INFRARED DYE-CONJUGATED HYALURONIC ACID DERIVATIVE AND CONTRAST AGENT FOR OPTICAL IMAGING INCLUDING THEM

摘要

Provided is a compound having a high ICG content that has high accumulation property in a tumor and has a large intensity of a photoacoustic signal emitted from the tumor even when a time period elapses after administration. Specifically, provided is a hyaluronic acid derivative to which polyethylene glycol and an ICG derivative are conjugated.

主权项

1. A compound, comprising a polymer formed of units each represented by general formula (1): wherein: R1's are independent of each other from unit to unit in the general formula (1); and the polymer contains at least one unit having one of general formula (2) and general formula (25) as R1 in the general formula (1), and at least one unit having general formula (3) as R1 in the general formula (1): provided that: in the general formula (2), the general formula (3), and the general formula (25), L's represent linkers independent of each other from unit to unit, and * represents a binding site with N in the general formula (1); and in the general formula (3), R2 represents any one of H, OH, OMe, NH2, and COOH, and k represents an integer of 20 or more and 200 or less.