| 摘要 |
Compounds or pharmacologically acceptable salts thereof for promoting osteogenesis, improving bone metabolism, preventing or treating bone fracture, preventing or treating a disease associated with bone metabolism, or in the field of orthopedics for the promotion of healing of bone fracture, a bone defect, and bone diseases such as osteoarthritis as well as in the field of dentistry for the treatment of periodontal disease and the stabilization of artificial tooth root. The compounds are represented by formula (I) or a pharmacologically acceptable salt thereof:; |
| 主权项 |
1. A compound represented by the general formula (I) or a pharmacologically acceptable salt thereof: wherein each substituent is defined as follows: R1 represents a halogen atom, a cyano group, a vinyl group, an allyl group, a nitro group, an amino group, a C3-C6 cycloalkyl group, a C1-C6 alkyl group optionally substituted by one or two or more groups selected from substituent group a, a C1-C6 alkoxy group optionally substituted by one or two or more groups selected from substituent group a, a C1-C6 alkylamino group optionally substituted by one or two or more groups selected from substituent group a, a di-C1-C6 alkylamino group optionally substituted by one or two or more groups selected from substituent group a, or a heterocyclic group optionally substituted by one or two or more groups selected from substituent group a, wherein
the substituent group a consists of a C3-C6 cycloalkyl group, a hydroxyl group, a halogen atom, an oxo group, and a phenyl group; R2 represents a hydrogen atom or a protective group for the hydroxyl group; R3 represents a hydrogen atom, a halogen atom, or a C1-C6 alkyl group; R4 represents a hydrogen atom or a C1-C6 alkyl group optionally substituted by a C1-C6 alkoxy group; and A represents a 4 piperidine group substituted by one or two or more groups selected from substituent group c, wherein
the substituent group c consists ofa hydroxyl group, a hydroxy-C1-C6 alkyl group, a C1-C6 alkylsulfonyl group, an aminocarbonyl group, a C1-C6 alkylaminocarbonyl group, a di-C1-C6 alkylaminocarbonyl group,a C3-C7 cycloalkylaminocarbonyl group, a heterocycle-carbonyl group,a C1-C6 alkoxy-C1-C6 alkylcarbonyl group, a C1-C6 alkylaminosulfonyl group,a di-C1-C6 alkylaminosulfonyl group,a C3-C7 cycloalkylsulfonyl group, a heterocycle-sulfonyl group,a C1-C6 alkyl group optionally substituted by one or two or more groups selected from substituent group d,a C1-C6 alkylcarbonyl group optionally substituted by one or two or more groups selected from substituent group d,a C1-C6 alkoxycarbonyl group optionally substituted by one or two or more groups selected from substituent group d,a heterocyclic group optionally substituted by one or two or more groups selected from substituent group d,a benzoyl group optionally substituted by one or two or more groups selected from substituent group d, anda benzyl group optionally substituted by one or two or more groups selected from substituent group d, whereinthe substituent group d consists ofa halogen atom, a carboxy group, an oxo group, an aminocarbonyl group, a C1-C6 alkoxy group,a C1-C6 alkoxycarbonyl group, a C1-C6 alkylaminocarbonyl group,a di-C1-C6 alkylaminocarbonyl group, a heterocycle-carbonyl group, a phenyl group, anda phenylaminocarbonyl group optionally substituted by one or two or more groups selected from substituent group e, whereinthe substituent group e consists ofa heterocycle-carbonyl group and a heterocycle-C1-C6 alkyl group. |
