WELL DRAIN SYSTEM FOR USE WITH MULTI-WELL SYNTHESIZER

摘要

A well drain system for use with a synthesizer. The well drain system comprises a well plate, a well adapter plate and a drain plate detachably coupled together. The well plate comprises a matrix of wells for receiving one or more vials, wherein the matrix has a plurality of rows. The well adapter plate comprises an arched plate body and a plurality of apertures in communication with one or more of the wells. The drain plate comprises a plurality of channels in communication with one or more of the apertures. As a result, a user is able to selectively drain the vials found within individual rows of the well plate instead of all the vials at once.

主权项

1. A method of draining a well drain system, the method comprising:
inserting a first plurality of vials into a first row of wells in a well drainage system, and a second plurality of vials into a second row of wells in the well drainage system, each of the first and second plurality of vials containing a solid support for synthesizing a polymer chain; simultaneously dispensing a reagent solution into each of the first plurality of vials; simultaneously dispensing the reagent solution into each of the second plurality of vials after having dispensed the reagent solution into each of the first plurality of vials; simultaneously draining the reagent material from each of the first plurality of vials by applying a pressure differential to a first output that is in fluid communication with each of the first plurality of wells, wherein the reagent material is drained after a first period of time has elapsed since dispensing the reagent solution into each of the first plurality of vials; and simultaneously draining the reagent material from each of the second plurality of vials by applying a pressure differential to a second output that is in fluid communication with each of the second plurality of wells, wherein the reagent material is drained after a second period of time has elapsed since dispensing the reagent solution into each of the second plurality of vials; wherein the first and second periods of time have the same duration.