发明名称 |
APPARATUSES AND METHODS FOR DETERMINING ANALYTE CHARGE |
摘要 |
The present disclosure provides a sensor including a pore and an applied electric field that is capable of detecting analytes such as nucleic acids. In accordance with various embodiments, the sensor comprises a fluidic chamber having electrically opposing portions with a membrane between, the membrane providing a pore suitable for the passage of an electrolyte between the electrically opposing portions of the fluidic chamber, and having at least one charged analyte tethered in proximity to the pore, a first circuit configured to apply an electric field capable of passing the electrolyte through the pore and pulling the at least one charged analyte into the pore, and a second circuit configured to measure a signal indicative of the charge of the at least one charged analyte. Also provided are methods for using the sensor, for example, to sequence a nucleic acid molecule. |
申请公布号 |
CA2951945(A1) |
申请公布日期 |
2015.12.23 |
申请号 |
CA20152951945 |
申请日期 |
2015.06.19 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
PAIK, KEE-HYUN;PERSSON, HENRIK H.J.;LAU, BILLY TSZ CHEONG;JI, HANLEE P.;DUTTON, ROBERT W.;LIU, YANG;DAVIS, RONALD W. |
分类号 |
G01N33/487 |
主分类号 |
G01N33/487 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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