发明名称 Strategic dynamic range control for time-of-flight mass spectrometry
摘要 A mass spectrometer of the type useful in mass cytometry includes an ion detector. A digitizing system for converting analog signals from the ion detector includes two analog-to-digital converters. The analog-to-digital converters are configured to provide an increased dynamic range for a targeted period while limiting the amount of data generated.
申请公布号 US9218949(B2) 申请公布日期 2015.12.22
申请号 US201313909721 申请日期 2013.06.04
申请人 Fluidigm Canada, Inc. 发明人 Tanner Scott D.
分类号 H01J49/40;H01J49/02 主分类号 H01J49/40
代理机构 Kilpatrick Townsend & Stockton LLP 代理人 Kilpatrick Townsend & Stockton LLP
主权项 1. A mass spectrometer comprising: ion optics for receiving ionized sample material from an ion source and conveying at least some ions from the ionized sample material through the ion optics; a time-of-flight mass analyzer coupled to the ion optics for receiving at least some of the ions conveyed by the ion optics, the mass analyzer comprising a time-of-flight chamber, an ion pulsing system for periodically generating an electrical field to direct groups of the received ions into the time-of-flight chamber, and an ion detector arranged to receive ions that have travelled through the time-of-flight chamber for generating a signal indicative of the number of ions arriving at the ion detector as a function of time, the signal including information about mass spectra of the groups of ions produced by the pulsing system; a digitizing system for receiving and digitizing the signal from the ion detector and for providing extended dynamic range data during a target period, the digitizing system comprising; first and second analog-to-digital converters, the first analog-to-digital converter being configured to receive and digitize the signal from the ion detector during a first time window coinciding with a first portion of each mass spectrum, and characterized by a low full scale voltage range; the second analog-to-digital converter being configured to receive and digitize the signal from the ion detector during a second time window coinciding with a second portion of each mass spectrum, and characterized by a high full scale voltage range; wherein the first and second time windows are offset time-wise relative to one another and overlap one another during the target period, and wherein the first and second time windows are selectively adjustable by a user to adjust the time window overlap during the target period.
地址 Markham CA