| 摘要 |
FIELD: medicine.SUBSTANCE: group of inventions relates to gel composition for local application, which contains from 0.05 to 0.20 wt % of methylparaben as preservative; one or more additional preservatives; from 0.80 to 1.50 wt % of carbomer; from 9.0 to 13.0 wt % of the total content of polyatomic alcohols, in particular propyleneglycol and glycerol; active ingredient, containing agonist of alpha-adrenergic receptors or its pharmaceutically acceptable salt, in particular brimonidine tartrate, and purified water, in which the total quantity of all ingredients equals 100%, composition pH constitutes from 4.5 to 7.5, and where when methylparaben concentration is higher than 0.15 wt %, carbomer concentration constitutes less than 1.25 wt %, and to method of treatment or prevention of skin disease in patient.EFFECT: creation of improved gel composition for local application, which in fact does not contain methylparaben crystals and possesses microbiological purity.15 cl, 2 ex, 3 tbl |
