CHIMERIC CAPSIDS

摘要

The present invention relates to viral vectors and methods of their production and use. Specifically, the disclosure provides compositions and methods for adeno-associated viral (AAV) vector production, wherein AAV vector comprising chimeric polynucleotides encoding chimeric capsid for improved compositions production. Further disclosed are variable regions (VR) in different AAV serotypes for producing a chimeric capsid, and methods for delivering transgenes using the vectors produced.