Pluraflavins and derivatives thereof, process for their preparation and use thereof

摘要

The invention relates to a compound of formula (I) wherein R1 is sugar, R2 is -COOH or R2 is -CH2-O-(R7)m, R7 representing a sugar, R3 is an epoxide-comprising group, C1-C6-alkyl or C2-C6-alkenyl, unsubstituted or substituted by at least one OH, R5 is H, C1-C6-alkyl, C2-C6-alkenyl or C2-C6-alkynyl, R4, R6, R8 and R10 independently of one another are H, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, -X2H or -X2R12 or R4 and R6 together and/or R8 and R10 together are =X2, X2 is O, NH, N-C1-C6-alkyl, N-C2-C6-alkenyl, N-C2-C6-alkynyl or S, R12 is C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, aryl or acyl, and m and n are 1 or 2 and its physiologically acceptable salts. The compounds are obtainable from a culture of the microorganism Actinomycetales species HAG 003959, DSM 12931, by fermentation. Accordingly, the invention relates to a process for their preparation and to the use of the compounds as pharmaceuticals, for example as anti-tumor agents.