FUNCTIONAL NUCLEIC ACID LIGANDS TO FLUORESCENT PROTEINS
摘要
The present invention relates to a nucleic acid aptamer having a first domain that binds to a fluorescent protein. The nucleic acid aptamer forms a molecular complex whereby the aptamer binds a fluorescent protein at the first domain. A constructed DNA molecule, expression systems, and host cells containing the molecular complex are also disclosed. The invention also relates to a system containing a first DNA molecule encoding the nucleic acid aptamer of the present invention and a second DNA molecule encoding a fluorescent protein capable of being bound by the first domain. Methods of detecting a molecular target and determining location of a molecular target using the nucleic acid aptamer of the invention are also disclosed.
申请公布号
WO2007147159(A3)
申请公布日期
2008.12.24
申请号
WO2007US71470
申请日期
2007.06.18
申请人
CORNELL RESEARCH FOUNDATION, INC.;KOTLIKOFF, MICHAEL;LIS, JOHN, T.;SHUI, BO;SHI, HUA