Preparation of pharmaceutical salts of piperazine compounds
摘要
The present invention is generally directed to a process to directly prepare pharmaceutically acceptable salts enriched with respect to selected rotameric salts of a basic compound, by creative choice of an acid and a solvent medium. The process is particularly useful in preparing specific rotamers of pharmaceutically useful salts in desired preponderance of a rotamer.
申请公布号
ZA200705514(B)
申请公布日期
2008.09.25
申请号
ZA20070005514
申请日期
2007.07.05
申请人
SCHERING CORPORATION
发明人
WU, WENXUE;D'SA, BOSCO;LEONG, WILLIAM;KLOPFER, KEVIN;TRAN, LOC THANH;LIANG, FENG;LEE, HONG-CHANG;SABESEN, VIJAY