EXPRESSION VECTOR FOR MASS PRODUCTION OF FOREIGN GENE-DERIVED PROTEIN USING ANIMAL CELL AND USE THEREOF

摘要

The present inventors successfully constructed an expression vector which comprises a gene cassette containing a drug-resistant gene cistron with reduced expression and a property of impairing translation and having a cloning site for insertion of a foreign gene between a highly transcriptionally active promoter and a highly stable polyadenylation signal and is capable of producing a foreign gene-derived protein at a high level in a mammalian host cell.