摘要 |
<p>593058 Disclosed is (R)-3-((E)-2-(Pyrrolidin-3-yl)vinyl)-5-(tetrahydropyran-4-yloxy)pyridine mono-L-malate or a hydrate or solvate thereof. Also disclosed is a pharmaceutical composition comprising the compound and the use of the compound in the manufacture of a medicament for the treatment of NNR mediated disorders such as CNS disorders, inflammation, inflammatory response associated with bacterial and/or viral infection, pain, metabolic syndrome, autoimmune disorders wherein the CNS disorder is selected from cognitive dysfunction in schizophrenia (CDS), Alzheimers Disease (AD), attention deficit disorder (ADD), pre-senile dementia (early onset of Alzheimer's Disease), dementia of the Alzheimer's type, mild cognitive impairment, age associated memory impairment, and attention deficit hyperactivity disorder (ADHD).</p> |
申请人 |
TARGACEPT, INC. |
发明人 |
AKIREDDY, SRINIVISA, RAO;BREINING, SCOTT, R;CUTHBERTSON, TIMOTHY, J;DULL, GARY, MAURICE;GATTO, GREGORY, J;GENUS, JOHN;HAMMOND, PHILIP, S;MITCHENER, JOSEPH, PIKE, JR;MUNOZ, JULIO, A;OTTEN, PIETER, ALBERT;YOHANNES, DANIEL;FEDOROV, NIKOLAI |