发明名称 |
Rupturing controlled release device comprising a subcoat |
摘要 |
The present invention provides a simple and improved rupturing controlled release device that is capable of providing a controlled release of active agent contained in the core first through a preformed passageway and then through an in situ formed second passageway into an environment of use in a standardized release profile manner. The rupturing controlled release device comprises a core comprising at least one drug and at least one osmopolymer, a semipermeable membrane enclosing the core and having at least one preformed passageway there through, wherein the semipermeable membrane ruptures during use to form a second passageway in the semipermeable membrane at a location spaced away from the preformed passageway, and a release-controlling subcoat between the core and the semipermeable membrane. |
申请公布号 |
US8637080(B2) |
申请公布日期 |
2014.01.28 |
申请号 |
US20080146069 |
申请日期 |
2008.06.25 |
申请人 |
PASTINI ANA C.;FAOUR JOAQUINA;VERGEZ JUAN A.;RICCI MARCELO A.;FISCHBEIN GUSTAVO A.;OSMOTICA KERESKEDELMI ES SZOLGALTATO, KFT |
发明人 |
PASTINI ANA C.;FAOUR JOAQUINA;VERGEZ JUAN A.;RICCI MARCELO A.;FISCHBEIN GUSTAVO A. |
分类号 |
A61K9/00;A61K31/195;A61K31/403;A61K31/4422;A61K31/519;A61K31/55;A61K31/5513 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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