| 主权项 |
1. A method for manufacturing a catheter comprising a hydrophilic gel, said method comprising the steps of:
a) combining a polymeric photoinitiator of the general formula I:
R1(A1)r-(R2(A2)m-O)o—(R3(A3)n-O)p—R4(A4)s (I) wherein R2 and R3 are independently at each occurrence identical or different, linear or branched alkylene or cycloalkylene groups; wherein R2 and R3 may be substituted with one or more substituents selected from CN; azides, esters; ethers; amides; halogen atoms; sulfones; sulfonic derivatives; NH2 or Nalk2, where alk is any C1-C8 straight chain alkyl group, C3-C8 branched or cyclic alkyl group; R1 and R4 are independently at each occurrence identical or different, linear or branched alkyl or cycloalkyl groups or aryl groups or are independently at each occurrence selected from H, OH, CN, halogens, amines, amides, alcohols, ethers, thioethers, sulfones and derivatives thereof, sulfonic acid and derivatives thereof, sulfoxides and derivatives thereof, carbonates, isocyanates, nitrates, acrylates, polyethylenes, polyethylene oxides, polyvinyl pyrrolidones, polypropylenes, polyesters, polyamides, polyacrylates, polystyrenes, and polyurethanes; and when R1 and R4 are alkyl and aryl groups, they may be substituted with one or more substituents selected from CN; OH; azides; esters; ethers; amides; halogen atoms; sulfones; sulfonic derivatives; NH2 or Nalk2, where alk is any C1-C8 straight chain alkyl group, C3-C8 branched or cyclic alkyl group; o and p are each a real number from 0-5000 provided that o+p>0; m and n are each a real number from 0-10, provided that m+n>0; r and s are each a real number from 0-5; provided at least one of m or n is at least 1; and A1, A2, A3 and A4 are identical or different photoinitiator moieties linked to R1, R2, R3, and R4, respectively, via an alkylene ether spacer group comprising (—(CH2CH2—O)t—, wherein t is from 1-100; with one or more gel-forming polymers and/or gel-forming monomers to form a matrix composition, b) curing the matrix composition obtained in step a. by exposing it to UV radiation, c) exposing the matrix composition to a swelling medium, d) incorporating the hydrophilic gel/matrix composition into a catheter,wherein steps b) and c) may take place in any order, provided that, if step d) is carried out first, step b) takes place before step c). |
