ACTIVE MICRO SIEVE AND METHODS FOR BIOLOGICAL APPLICATIONS

摘要

An active sieve device for the isolation and characterization of bio-analytes is provided, comprising a substrate for supporting the bio-analytes. The substrate comprises a plurality of interconnections and a plurality of regions, each region comprising a hole and at least one electrode embedded in or located on the substrate and electrically associated with the hole. Each region further comprises at least one transistor integrated in the substrate and operably connected to the at least one electrode and to at least one of the plurality of interconnections.

主权项

1. A method for analyzing bio-analytes with an active sieve device, comprising:
introducing a medium comprising at least one bio-analyte into an active sieve device, the active sieve device comprising:
a substrate configured for supporting a bio-analyte, the substrate comprising a plurality of interconnections and a plurality of regions, wherein each region comprises:
a hole;at least one electrode electrically associated with the hole and embedded in or located on the substrate; andat least one transistor integrated in the substrate and operably connected to the at least one electrode and to at least one of the plurality of interconnections;isolating the at least one bio-analyte with the active sieve device;performing at least one measurement on the at least one isolated bio-analyte by driving the transistors; andidentifying at least one targeted bio-analyte using the at least one measurement.