Chromatography Media For Purifying Vaccines And Viruses

摘要

Adsorptive media for chromatography, particularly ionexchange chromatography, derived from a shaped fiber, useful for purifying viruses. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Surface pendant functional groups can be added that provides ion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of viruses, such as influenza.

主权项

1. A process of purifying a virus in a sample, comprising contacting said sample with a bed of fiber media, the fibers in said media comprising a body region and a plurality of projections extending from said body region, said fibers having imparted thereon functionality enabling chromatography.