| 发明名称 |
SIMIAN ADENOVIRUS NUCLEIC ACID AND AMINO ACID SEQUENCES, VECTORS CONTAINING SAME, AND METHODS OF USE |
| 摘要 |
A recombinant vector comprises simian adenovirus sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses simian adenovirus gene(s) is also disclosed. Methods of using the vectors and cell lines are provided. |
| 申请公布号 |
US2015352203(A1) |
申请公布日期 |
2015.12.10 |
| 申请号 |
US201514824336 |
申请日期 |
2015.08.12 |
| 申请人 |
The Trustees of the University of Pennsylvania |
发明人 |
Wilson James M.;Gao Guangping;Roy Soumitra |
| 分类号 |
A61K39/235;C12N15/86;C07K14/005;C12N7/00 |
主分类号 |
A61K39/235 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A recombinant adenovirus having a capsid comprising a SV39 hexon protein having the amino acid sequence of SEQ ID NO: 36, having packaged therein a nucleic acid sequence comprising (a) an adenovirus 5′ inverted terminal repeat sequence, (b) a nucleotide sequence heterologous to SV39 encoding a therapeutic or immunogenic product operably linked to expression control sequences which direct transcription, translation, and/or expression thereof in a host cell, and (c) an adenovirus 3′ inverted terminal repeat sequence. |
| 地址 |
Philadelphia PA US |
