发明名称 |
NHE3-BINDING COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT |
摘要 |
Provided are NHE3-binding and/or NHE3-modulating agents having activity as phosphate transport inhibitors, including inhibitors of phosphate transport in the gastrointestinal tract and the kidneys, and methods for their use as therapeutic or prophylactic agent.. Embodiments of the present invention include methods for inhibiting phosphate uptake in the gastrointestinal tract or kidneys of a patient in need of phosphate lowering, comprising administering to the patient a compound that binds to NHE3 and is substantially active in the gastrointestinal tract or kidneys to inhibit transport of phosphate ions (Pi) therein upon administration to the patient in need thereof. |
申请公布号 |
WO2014169094(A3) |
申请公布日期 |
2015.10.29 |
申请号 |
WO2014US33603 |
申请日期 |
2014.04.10 |
申请人 |
ARDELYX, INC |
发明人 |
CARRERAS, CHRISTOPHER;CHARMOT, DOMINIQUE;JACOBS, JEFFREY, W.;LABONTE, ERIC;LEWIS, JASON, G. |
分类号 |
A61K31/472 |
主分类号 |
A61K31/472 |
代理机构 |
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