| 发明名称 |
METHODS FOR TREATMENT OF MELANOMA |
| 摘要 |
Embodiments of the present invention are directed to methods for treatment of melanoma using an inhibitor of dihydroorotate dehydrogenase (DHODH) and to combination therapies that involve administering to a subject an inhibitor of oncogenic BRAF (e.g. BRAF(V600E)), as well as an inhibitor of dihydroorotate dehydrogenase (DHODH). Assays for identifying compounds useful for the treatment of melanoma are also provided. The methods comprise screening for compounds or agents that inhibit neural crest progenitor formation in a zebra fish model of melanoma. |
| 申请公布号 |
US2015306080(A1) |
申请公布日期 |
2015.10.29 |
| 申请号 |
US201514733498 |
申请日期 |
2015.06.08 |
| 申请人 |
Children's Medical Center Corporation ;Dana-Farber Cancer Institute, Inc. |
发明人 |
Zon Leonard;White Richard M. |
| 分类号 |
A61K31/44;A61K31/437;A61K45/06;A61K31/196 |
主分类号 |
A61K31/44 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A method for treating melanoma in a subject comprising administering to a subject in need thereof a therapeutically effective amount of an inhibitor of dihydroorotate dehydrogenase (DHODH), wherein the inhibitor of DHODH is selected from the group consisting of: C19H14F2N2O3; C18H13F6NO4; C19H16F3NO4; C19H10F5NO4S; C19H14FNO4S; C20H15F4NO4; C19H17NO4; C20H17F2NO4; and C20H18FNO4. |
| 地址 |
Boston MA US |
