Peptidomimetics and their application

摘要

Novel peptidomimetics exhibiting affinity for opioid receptors, possessing a general formula shown in FIG. 1, for gastrointestinal or peripheral administration in the form of a pill, infusion, injection or implant in the treatment of peripheral opioids side effects, particularly constipation or/and respiratory depression.

主权项

1. Compound with the general formula: where: R1 is a side chain of an amino acid where the amino acid is selected from D-alanine, D-threonine, D-serine, D-methionine, D-leucine, D-glutamine, D-asparagine, D-arginine, and D-lysine; R2 denotes nothing or residue of glycine or dipeptide selected from among Gly-Phe, Gly-Trp.