METHOD FOR SECRETORY PRODUCTION OF PROTEIN

摘要

A method for secretory production of a heterologous protein is provided by developing a novel technique for improving ability of a coryneform bacterium to produce a heterologous protein by secretory production. By utilizing a coryneform bacterium having an ability to produce a heterologous protein by secretory production which has been modified so that activity of a penicillin binding protein is reduced and in which activity of a cell surface layer protein has been reduced as an expression host a heterologous protein is produced by secretory production.