BIOMARKERS FOR PREDICTING CLINICAL RESPONSE OF CANCER PATIENTS TO TREATMENT WITH IMMUNOTHERAPEUTIC AGENT

摘要

Provided herein are prognostic and diagnostic methods for predicting likelihood of clinical response of a subject having cancer to treatment with an immunotherapeutic agent. Also provided herein are methods for treating a subject having cancer with an immunotherapeutic agent after determining likelihood of clinical response of the subject to such treatment.

主权项

1. A method for treating a subject having cancer with an immunotherapeutic agent, comprising
determining expression level of at least one gene in a blood sample obtained from the subject,
wherein the at least one gene is selected from a first group of genes as listed in Table 2 and a second group of genes as listed in Table 3; determining likelihood of clinical response of the subject to the treatment based on the expression level of the at least one gene in the blood sample,
wherein the expression level of the at least one gene selected from the first group of genes is positively correlated with the likelihood of clinical response, andwherein the expression level of the at least one gene selected from the second group of genes is negatively correlated with the likelihood of clinical response; and administering to the subject a therapeutically effective amount of the immunotherapeutic agent for treating the cancer.