| 摘要 |
The present invention relates to pharmaceutical technical field, to melonine bisindole compounds, pharmaceutical compositions thereof, and preparation methods thereof. Specifically, the present invention relates to melonine bisindole compounds of Formula I, pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts thereof. The present invention further relates to method for preparing the melonine bisindole compounds of Formula I or pharmaceutically acceptable salts thereof, and the use of the melonine bisindole compounds of Formula I or pharmaceutically acceptable salts thereof in the manufacture of a medicament for the treatment or prophylaxis of cancers.; |
| 主权项 |
1. A bisindole compound of Formula I or a pharmaceutically acceptable salt thereof,wherein,
ring A has a structure of Formula III: each R1 independently is hydrogen, hydroxyl, one or more halogen atoms, or oxo group; each R2 independently is hydrogen, hydroxyl, C1-10 alkyl, C1-10 aldehyde group, C1-10 alkylacyl, C1-10 alkoxy, C2-10 alkenoxy, C2-10 alkynoxy, or one or more halogen atoms F, Cl, Br, or I; or when the dash line to which the carbon atom linking R2 in Formula I links is a single bond, the R2 does not exist; each R3 independently is hydrogen, hydroxyl, C1-10 alkoxy, C2-10 alkenoxy, C2-10 alkynoxy or C6-10 aryloxo; each R4 independently is hydrogen, hydroxyl, C1-10 alkoxy, C2-10 alkenoxy, C2-10 alkynoxy or C6-10 aryloxo; each n is independently 0, 1, 2, or 3, wherein the bisindole compound of Formula I is not melonine B having the structure: |
