METHOD AND COMPOSITION FOR CORRELATION OF SINGLE NUCLEOTIDE POLYMORPHISM IN VITAMIN K EPOXIDE REDUCTASE GENE AND WARFARIN DOSAGE

摘要

PROBLEM TO BE SOLVED: To provide a method of producing vitamin K dependent proteins using in-vitro host cells.SOLUTION: There is provided a method of producing a vitamin K dependent protein using host cells into which a nucleic acid encoding a vitamin K dependent protein, a nucleic acid encoding a vitamin K dependent carboxylase, and a nucleic acid encoding a vitamin K epoxide reductase are introduced. The vitamin K dependent protein is a coagulation factor, namely, factor VIII, factor IX, factor X, prothrombin, Protein C and Protein S.