METHODS FOR CLASSIFYING TUMORS AND USES THEREFOR

摘要

Disclosed are methods for classifying tumors into EGFR antagonist sensitive or resistant subtypes. Additionally, the present invention discloses methods for stratifying subjects with cancer into treatment subgroups based on whether their tumors fall into one of these subtypes and to methods for treating subjects so stratified.

主权项

1. A method for classifying an EGFR positive tumor into a subtype selected from an EGFR antagonist sensitive subtype or an EGFR antagonist resistant subtype, the method comprising, consisting or consisting essentially of analyzing the ligand-induced EGFR internalization status of the tumor, wherein an impaired or abrogated ligand-induced EGFR internalization status indicates that the tumor is an EGFR antagonist sensitive subtype and wherein an unimpaired ligand-induced EGFR internalization of status indicates that the tumor is an EGFR antagonist resistant subtype.