COMPOSITIONS COMPRISING TRANSNORSERTRALINE AND SEROTONIN RECEPTOR 1A AGONISTS/ANTAGONISTS AND USES THEREOF

摘要

PROBLEM TO BE SOLVED: To provide compositions including a transnorsertraline or a pharmaceutically acceptable salt thereof, a serotonin receptor 1A antagonist or a pharmaceutically acceptable salt or solvate thereof, and a serotonin receptor 1A agonist or a pharmaceutically acceptable salt or solvate thereof.SOLUTION: The present invention provides: compositions including (1S,4R)-transnorsertraline, and serotonin receptor 1A antagonist such as pindolol and lecozotan, a serotonin receptor 1A agonist such as buspirone and eltoprazine; and a method of treating neurological disorders such as depression, cognitive deficits, fibromyalgia, pain, and sleep related disorders by using the compositions.