| 发明名称 |
Screening of oocyte donor candidates based on the FMR1 gene |
| 摘要 |
Method of selecting oocyte donor candidates for oocyte donation. A number of triple CGG repeats on each allele of the isolated FMR1 gene is measured by using an assay, and an oocyte donor is selected for oocyte donation only if both alleles of the isolated FMR1 gene have more than 26 CGG repeats. |
| 申请公布号 |
US9157117(B2) |
申请公布日期 |
2015.10.13 |
| 申请号 |
US201414271607 |
申请日期 |
2014.05.07 |
| 申请人 |
|
发明人 |
Gleicher Norbert;Barad David H |
| 分类号 |
C12Q1/68;C07H21/02;C07H21/04;A61B17/435 |
主分类号 |
C12Q1/68 |
| 代理机构 |
Davidoff Hutcher & Citron LLP |
代理人 |
Davidoff Hutcher & Citron LLP ;Siegel David H. |
| 主权项 |
1. A method of improving oocytes from an oocyte donor, comprising:
isolating an FMR1 gene from the oocyte donor; measuring the number of triple CGG repeats on each allele of the isolated FMR1 gene by using an assay; determining that the number of triple CGG repeats on at least one of the alleles of the isolated FMR1 gene is less than 26; administering an FMR1 inhibitor to the oocyte donor to reduce expression of the oocyte donor's FMR1 gene when it is determined that the number of triple CGG repeats on at least one of the alleles of the isolated FMR1 gene is less than 26; and thereafter harvesting an oocyte from the oocyte donor. |
| 地址 |
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