CD19 BINDING AGENTS AND USES THEREOF

摘要

This invention, inter alia, relates to CD19 binding agents and methods of using such CD19 binding agents for treating disease.

主权项

1. A method for treating a CD19-associated disorder in a mammalian subject comprising administering an antibody or antigen-binding fragment that specifically binds to human CD19 in an amount effective to treat the disorder in the mammalian subject; the antibody or antigen-binding fragment comprising a heavy chain variable region amino acid sequence as set forth in SEQ ID NO:29 with 0, 1 or 2 substitutions relative to SEQ ID NO:9 and a light chain variable region amino acid sequence as set forth in SEQ ID NO:30 with 0, 1 or 2 substitutions relative to SEQ ID NO:17; wherein the antibody or antigen-binding fragment binds to CD19 with a dissociation constant of 1×10−7 M.