| 发明名称 | Variant of antihemophilic factor VIII having increased specific activity | ||
| 摘要 | The present invention is in the field of hemophilia therapy. It relates to a new variant of antihemophilic factor VIII having increased specific activity in comparison to known factor VIII products. | ||
| 申请公布号 | US9150637(B2) | 申请公布日期 | 2015.10.06 |
| 申请号 | US201113883244 | 申请日期 | 2011.11.04 |
| 申请人 | BAXALTA INC.;BAXALTA GMBH | 发明人 | Lai Chee Kong;Stafford Roddy Kevin |
| 分类号 | A61K38/38;C07K14/755;A61K38/00 | 主分类号 | A61K38/38 |
| 代理机构 | Marshall, Gerstein & Borun LLP | 代理人 | Marshall, Gerstein & Borun LLP |
| 主权项 | 1. An isolated and recombinant, fully or partially B-domain deleted porcine factor VIII (FVIII) variant, the FVIII variant being devoid of an amino acid sequence corresponding to amino acids 716 to 742 of porcine factor VIII as depicted in FIG. 2 or amino acids 714 to 740 of SEQ ID NO: 7. | ||
| 地址 | Bannockburn IL US | ||