A METHOD TO IMPROVE THE TUMOR DIAGNOSTIC EFFICIENCY OF MULTIVALENT LIGANDS BY REGULATING THE STOICHIOMETRIC RATIO BETWEEN INNER SURFACE FUNCTIONALITIES AND LIGAND MOIETIES FOR TUMOR TARGETING

摘要

The present invention relates to a method for improving tumor diagnostic efficiency by controlling the ratio of inner surface functionality of a multivalent ligand and a ligand moiety of a tumor target, and a multivalent ligand for diagnosing a tumor. According to the present invention, the ratio of the inner surface functionality of the multivalent ligand and the ligand moiety of the tumor target is controlled to administer the same to a living body when diagnosing the tumor. If a ligand moiety binds to a specific receptor which is expressed on a surface of tumor cells in advance, a phenomenon, in which other homogeneous receptors are gathered around the bound receptor, occurs. Other ligand moiety, which could not be bound, is bound more easily to the gathered receptors in a multivalent manner. A type of the inner surface functionality, which is appropriately selected to be closer to a cell surface due to the bound ligand moiety, interacts with the surface of the tumor cells by an attractive force, thereby significantly improving the avidity in which the ligand moiety, which could not be bound, additionally and simultaneously is bound to the gathered receptors.