| 主权项 |
1. A compound according to Formula (I):wherein:
R5 and R6 are independently selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl, wherein alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl are optionally substituted one or more times and wherein two substituents in the cycloalkyl-, aryl-, or heteroarylring when taken together with the nitrogen or carbon to which they are attached optionally complete an additional 3- to 8-membered ring containing carbon atoms and optionally containing one or more heteroatoms selected from O, SOx, or NR50 and which is optionally substituted or partially saturated; R1, R2, R3, R4 are independently selected from the group consisting of hydrogen, deuterium, alkyl, deuteroalkyl, CD3, haloalkyl, fluoroalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl-alkyl, arylalkyl, heteroarylalkyl, COOR10, CONR10R11, SO2R10 and SO2NR10R11 wherein alkyl, haloalkyl, fluoroalkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl-alkyl, arylalkyl, and heteroarylalkyl are optionally substituted one or more times; R10 and R11 are independently selected from the group consisting of hydrogen, deuterium, alkyl, deuteroalkyl, CD3, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, fluoroalkyl, heterocycloalkylalkyl, haloalkyl, alkenyl, alkynyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl and aminoalkyl, wherein alkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, fluoroalkyl, heterocycloalkylalkyl, alkenyl, alkynyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl and aminoalkyl are optionally substituted, or R10 and R11 when taken together with the nitrogen to which they are attached complete a 3- to 8-membered ring containing carbon atoms and optionally containing a heteroatom selected from O, S, or NR50 and which is optionally substituted; R22 and R23 are independently selected from the group consisting of hydrogen, deuterium, halo, alkyl, deuteroalkyl, CD3, cycloalkyl, hydroxy, alkoxy, aryl, heteroaryl, arylalkyl, heteroarylalkyl, alkenyl, alkynyl, NO2, NR10R11, NR10NR10R11, NR10N═CR10RU, NR10SO2R11, CN, COOR10, and fluoroalkyl, wherein alkyl, cycloalkyl, alkoxy, alkenyl, alkynyl, and fluoroalkyl are optionally substituted; R50 is selected from the group consisting of hydrogen, deuterium, deuteroalkyl, CD3, alkyl, aryl, heteroaryl, C(O)R10, C(O)NR10R11, SO2R10 and SO2NR10R11, wherein alkyl, aryl, and heteroaryl are optionally substituted; x is selected from 0 to 2; or N-oxides, pharmaceutically acceptable salts, prodrugs, formulations, polymorphs, tautomers, racemic mixtures, optically active enantiomers, diasterioisomers, or stereoisomers thereof. |
