PYRIDAZINON-DERIVATE ALS CDK2-HEMMER

摘要

4-(Carboxamido or acylamino)-6-(hetero)aryl-3-oxo-2,3-dihydropyridazines (I) are new. 4-(Carboxamido or acylamino)-6-(hetero)aryl-3-oxo-2,3-dihydropyridazines of formula (I) (including racemates, enantiomers, diastereomers and their mixtures and tautomers) and their salts are new. A = -CO-NHR or -NH-COR; R = 1-6C alkyl, aryl, aryl-(1-6C) alkyl, heteroaryl, heteroaryl-(1-6C) alkyl, aryl or heteroaryl fused with cycloalkyl (1-10C), heterocycle, cycloalkyl, adamantyl, polycycloalkyl, alkenyl or alkynyl (all optionally substituted by one or more of halo, CN, NO2, NH2, OH, OR1, COOH, COOR1, OCOR1, NR1R2, NHCOR1, CONR1R2, SR1, SOR1, SO2R1, NHSO2R1, SO2NR1R2, CSNR1R2, NHCSR1, OSO2R1, SO2OR1, aryl, heteroaryl, CHO, CF3, SCF3 or OCF3); Ar = 6 membered aromatic ring containing 0-6 N (specifically phenyl or pyridyl) (optionally substituted by one or more of halo, CN, NO2, NH2, OH, OR1, COOH, COOR1, OCOR1, NR1R2, NHCOR1, CONR1R2, NHCSR1, CSNR1R2, SR1, SOR1, SO2R1, NHSO2R1, SO2NR1R2, OSO2R1, SO2OR1, CHO, CF3 or OCF3); R1, R2 = H, 1-6C alkyl, aryl, aryl-(1-6C) alkyl, alkenyl, alkynyl or heteroaryl (all optionally substituted by one or more of halo, 1-6C alkyl, 1-6C alkoxy, CN, NO2, OH, COOH, alkoxycarbonyl, CONH2, CHO, CF3 or OCF3).