摘要 |
<p>PDE4 inhibitors, pharmaceutical compositions including the inhibitors, and methods of treatment using the inhibitors are disclosed. The compounds are illustrated by Formulas 1-9 in the specification. The compounds can be used to treat a variety of disorders mediated by phosphodiesterase, and TNF-a, including asthma, chronic bronchitis, chronic obstructive pulmonary disease, arthritis, respiratory distress syndrome, allergic rhinitis, neurogenic inflammation, pain, rheumatoid arthritis, central nervous system disorders, cardiovascular disorders, and tumor progression.</p> |
申请人 |
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL;GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.;HENGMING, KE;KAUR, GURPREET;WANG, BINGHE;ZHENG, SHI-LONG |
发明人 |
HENGMING, KE;KAUR, GURPREET;WANG, BINGHE;ZHENG, SHI-LONG |